Circulating Cancer Cells (CCC) are cells that have detached from the primary tumor and are circulating in the bloodstream (initial phase of tumor invasion). CCC are not only very rare and fragile, they are also of different types, some of them much more invasive than others. Moreover, they are not the only rare cells in the blood, as other non-tumor cells, deriving from organs, may be present.
CCC could cause metastases, and circulate in blood for months, or even years, before metastasis formation. Therefore, they provide an amazing tool to identify patients at risk of developing metastases.
It has been a real challenge to develop a method allowing the isolation without loss of all types of CCC from the blood of patients, irrespectively of the type of solid cancer, while preserving the integrity of CCC. ISET® has proven it can overcome this challenge. It is the only method, based on blood filtration, to have been clinically validated.